| 2021-07-24 14:30:3524th July 2021 | Risca United  | 14:30:352:30 pm |  Afan Lido | JD Cymru (South) | N/A |
| 2021-07-27 19:30:0727th July 2021 | Afan Lido | 19:30:077:30 pm |  Swansea University | JD Cymru (South) | N/A |
| 2021-07-30 19:30:4130th July 2021 | Afan Lido | 19:30:417:30 pm |  Llanelli Town | JD Cymru (South) | N/A |
| 2021-08-10 19:30:5210th August 2021 | Afan Lido | 19:30:527:30 pm |  Undy Athletic | JD Cymru (South) | N/A |
| 2021-08-14 14:30:1314th August 2021 | Llantwit Major  | 14:30:132:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-08-20 19:30:4520th August 2021 | Taffs Well  | 19:30:457:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-08-24 19:30:0824th August 2021 | Afan Lido | 19:30:087:30 pm |  Ammanford | JD Cymru (South) | N/A |
| 2021-08-27 19:30:2827th August 2021 | Afan Lido | 19:30:287:30 pm |  Briton Ferry Llansawel | JD Cymru (South) | N/A |
| 2021-09-10 19:30:5810th September 2021 | Cambrian & Clydach  | 19:30:587:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-09-17 19:30:2617th September 2021 | Afan Lido | 19:30:267:30 pm |  Goytre United | JD Cymru (South) | N/A |
| 2021-10-01 19:30:441st October 2021 | Ammanford | 19:30:447:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-10-22 19:30:5722nd October 2021 | Afan Lido | 19:30:577:30 pm |  Cwmbran Celtic | JD Cymru (South) | N/A |
| 2021-10-30 14:30:2230th October 2021 | Afan Lido | 14:30:222:30 pm |  Carmarthen Town | JD Cymru (South) | N/A |
| 2021-11-06 14:00:556th November 2021 | Trefelin  | 14:00:552:00 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-11-19 19:30:1819th November 2021 | Afan Lido | 19:30:187:30 pm |  Pontypridd Town | JD Cymru (South) | N/A |
| 2021-12-03 19:30:353rd December 2021 | Pontypridd Town | 19:30:357:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-12-10 19:30:2410th December 2021 | Afan Lido | 19:30:247:30 pm | Trefelin | JD Cymru (South) | N/A |
| 2021-12-17 19:30:3117th December 2021 | Carmarthen Town | 19:30:317:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2021-12-27 18:00:5827th December 2021 | Afan Lido | 18:00:586:00 pm |  Port Talbot Town | JD Cymru (South) | N/A |
| 2022-01-01 14:30:311st January 2022 | Port Talbot Town | 14:30:312:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-01-21 19:30:3921st January 2022 | Goytre United | 19:30:397:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-01-28 19:30:1928th January 2022 | Afan Lido | 19:30:197:30 pm | Cambrian & Clydach | JD Cymru (South) | N/A |
| 2022-02-12 14:00:5312th February 2022 | Cwmbran Celtic | 14:00:532:00 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-02-25 19:30:4825th February 2022 | Briton Ferry Llansawel | 19:30:487:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-03-04 19:30:174th March 2022 | Swansea University | 19:30:177:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-03-11 19:30:4911th March 2022 | Afan Lido | 19:30:497:30 pm | Llantwit Major | JD Cymru (South) | N/A |
| 2022-03-19 14:00:2319th March 2022 | Undy Athletic | 14:00:232:00 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-04-01 19:30:341st April 2022 | Afan Lido | 19:30:347:30 pm | Taffs Well | JD Cymru (South) | N/A |
| 2022-04-08 19:30:428th April 2022 | Llanelli Town | 19:30:427:30 pm | Afan Lido | JD Cymru (South) | N/A |
| 2022-04-23 14:30:5123rd April 2022 | Afan Lido | 14:30:512:30 pm | Risca United | JD Cymru (South) | N/A |
